JC1 - "I've Got the Power" and "Taking Out The Garbage".

JC2 - Any missions that have hacking. The hacking is by far the most difficult part of gameplay. Actually, it's the only difficult thing in JC2.

JC3 - "Abandon Ship".

JC4 - Any where Rico has to defend some small location while defeating many waves of attackers. Also, "Extermination".

Any takeover missions in just cause 1 when tanks start spawning. Even with a chopper, the older controls and limited movement really hinders your ability to do well